First complete pictures of cells’ DNA-copying machinery

he first-ever electron microscope images of the protein complex that unwinds, splits, and copies double-stranded DNA reveal something rather different from the standard textbook view.The images, created by scientists at the U.S. Department of Energy’s Brookhaven National Laboratory with partners from Stony Brook University and Rockefeller University, offer new insight into how this molecular machinery functions, including new possibilities about its role in DNA “quality control” and cell differentiation.

he first-ever electron microscope images of the protein complex that unwinds, splits, and copies double-stranded DNA reveal something rather different from the standard textbook view.The images, created by scientists at the U.S. Department of Energy’s Brookhaven National Laboratory with partners from Stony Brook University and Rockefeller University, offer new insight into how this molecular machinery functions, including new possibilities about its role in DNA “quality control” and cell differentiation.

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